Henin and Williams have met eight times in their careers but Saturday's clash will be the first since the muscular American won a semi-final meeting with the Belgian at Wimbledon nearly four years ago.
Serena Williams produced 20 aces and blasted her way into the quarter-finals of the Sony Ericsson Open with a 7-5, 6-3 win over Australian Samantha Stosur on Monday.
McEnroe had claimed that Serena, who is the best player of her gender, would be ranked 700 if she plays on the men's circuit.
Installed by bookmakers as the favourite to win Wimbledon and a first grand slam title after stunning holder Serena Williams in the last 16 on Monday, Sabine Lisicki flashed a winning smile that belied any feelings of pressure.
Defending champion Jannik Sinner dismissed eighth seed Alex de Minaur 6-3, 6-2, 6-1 to reach the Australian Open semi-finals and extend the country's decades-long wait for another homegrown singles winner at the Grand Slam on Wednesday.
Top seed Serena Williams overcame a week fighting jet-lag to beat fellow American Coco Vandeweghe 7-5, 6-3 to retain the Stanford Classic title on Sunday.
Naomi Osaka's return a boost for women's tour, says Mouratoglou
"I'd like to thank all of the fans who have been so supportive. I'll be back... better than ever," said the world number three.
Serena Williams reached the Family Circle Cup semi-finals on Friday by beating number two seed Maria Sharapova 7-5, 4-6, 6-1 while Vera Zvonareva upset top seed Jelena Jankovic 6-2, 3-6, 6-2. Sharapova, who won only nine of 35 points in a final set during which Williams made only one unforced error, lost to the American for the fifth time in seven career matches.
Ruthless Serena Williams underlined her dominance at the top of women's tennis on Sunday, completing her year in style with a 6-2, 7-6 defeat of big sister Venus in the final of the WTA Championships.
Serena Williams easily won her eagerly-awaited clash with Sloane Stephens at the US Open on Sunday as normal service resumed at the last Grand Slam of year.
Serena Williams retained her Sony Ericsson Open title with a 6-1, 5-7, 6-3 win over fourth seed Jelena Jankovic in windy conditions on Saturday. The eighth-seeded American, who is now tied with Germany's Steffi Graf for the record of five Miami titles, triumphed on her eighth match point with an overhead smash.
Serena Williams revived memories of her two Australian Open titles by coming from a set and a break down to beat Russian fifth seed Nadia Petrova 4-6, 7-5, 6-3 and book a place in the fourth round on Friday.
The World No 2 announced her commitment to the social media entrepreneur shortly before the New Year and while it was "great", she was pushing it to the back of her mind, at least until after Melbourne Park.
Williams, who played an exhibition match last December in the United Arab Emirates, where she lost to French Open champion Jelena Ostapenko, said in addition to working on her serve and returns, she needs to manage her time better now that she has her daughter in tow.
Serena Williams overcame an even-numbered year hoodoo and the fairytale return of an opponent once ranked number one in the world to claim her 12th Grand Slam singles title at the Australian Open on Saturday.
Saturday's Australian Open showdown between Serena Williams and Justine Henin is more than a dream final between defending champion and comeback queen.
Nothing, absolutely nothing could stop Serena Williams from completing the magnificent TWO-O on Saturday and the American joyously bounced around as she hoisted a Grand Slam singles trophy for the 20th time with victory at the French Open.
Russia's Elena Dementieva defeated a hobbling Serena Williams 6-3, 6-2 at the Olympic tennis centre on Friday to win the Sydney International for the second year in a row.
Halep finds groove to reach Prague semi-finals.
Bumble began in 2014 as a dating platform for women to start discussions with potential male partners. The company is aiming to promote newer functions, Bumble BFF and Bumble Bizz, which help women find friends and build business networks, alongside dating.
American Serena Williams barged her way into the second round at Wimbledon on Monday with a 6-1 7-5 victory over Portuguese qualifier Neuza Silva.
Serena Williams lives by the worlds of Muhammad Ali: 'Being a champion isn't about what you do when you are on top; it's about what you do when you are knocked down'.
The 23-year-old studied at Harvard before turning professional on the tennis tour and Serena thinks he has got it all.
The veteran American set up a showdown with Romanian former world number one Simona Halep in Saturday's final.
Serena Williams is now one match away from reinforcing her stranglehold on the women's game by holding all four grand slam titles at the same time, a feat she will achieve for the second occasion if she beats 20th-seeded Spaniard Garbine Muguruza in Saturday's final.
Coco Gauff claimed the biggest win of her young career on Friday with a stunning upset of defending champion Naomi Osaka at the Australian Open to reach the fourth round. Caroline Wozniacki and Serena Williams also lost their respective matches earlier in the day. Images from Day 5 of the Australian Open played at Melbourne Park on Friday.
A preview of the Ladies semi-finals at Wimbledon.
Serena Williams roared into a her seventh Wimbledon singles final with a 6-3, 7-6 victory over Victoria Azarenka on Thursday. She will face Poland's Agnieszka Radwanska in Saturday's final.
A subdued Serena Williams recovered from a sluggish start to beat China's Zheng Jie 6-7, 6-2, 9-7 in a marathon Wimbledon third-round match on Saturday.
American Serena Williams won her fourth Wimbledon singles title on Saturday when she crushed Russian 21st seed Vera Zvonareva 6-3, 6-2 in the final at the All England Club.
'I'm an actress, model and an athlete. I put athlete third on my list,' the world No. 1 says.
Sania Mirza and Bethanie Mattek set up a quarter-final clash with American sisters Venus and Serena Williams after getting past the Uzbek-Belarussian pair of Akgul Amanmuradova and Darya Kustova in the third round of Wimbledon Championships.
Andy Roddick and Serena Williams scored contrasting wins to enter the Australian Open quarterfinals.
Serena Williams blew away fellow former number one Maria Sharapova 6-1, 6-3 to join top seed Victoria Azarenka in the semi-finals at the Madrid Open on Friday.
Serena Williams overcame a lethargic start to upset fellow former World No 1 Caroline Wozniacki at the Madrid Open on Thursday and set up a quarter-final meeting with old foe Maria Sharapova.
A pep talk from dad Richard and a timely downpour over Roland Garros rescued Serena Williams from an embarrassing first-round exit at the French Open on Sunday.